Franco Salomon Study
London, England - 1989

The Effects of Treatment with Recombinant
Human Growth Hormone on Body Composition and Metabolism
in Adults with Growth Hormone Deficiency
Salomon, Franco; Cuneo, RC; Hesp, R; Sönksen, PH.

Dr. Franco Salomon and colleagues, conducted a research study in London, England, in 1989. It lasted for a period of six months. They also gave [ synthetic ] Human Growth Hormone ( HGH ) to a group of adults. There were 24 of them in this group, who each had low levels of Growth Hormone ( GH ) in their bodies. In some ways, it was similar to the break-through study which Dr. Daniel Rudman performed about one year later.

This was a Double-Blind, Placebo-Controlled Research Trial. According to their final report and analysis, most of the individuals studied had developed a deficiency in their levels of Growth Hormone ( GH ) during adulthood. It was specifically noted that they all had previously received medical treatment for tumors in their Pituitary Glands ( where Growth Hormone is produced and stored ).

Additionally, each of those patients who participated in this study were receiving Hormone Replacement Therapy ( HRT ) for either Thyroid Glands, Adrenal Glands or Gonadal Glands.

The medical research team studied the effects of treating these people with specific amounts of [ synthetic ] Human Growth Hormone ( HGH ).  These patients were given a dose of recombinant Human Growth Hormone ( r-HgH ) at 0.07 U per kg of body weight, given under the skin at bedtime.

These are the results of their research study:

The mean plasma concentration of the Insulin-Like Growth Factor 1 ( IGF-1 ) increased from 0.41 ( ±0.05 ) to 1.53 ( ±0.16 ) U per liter during the administration of the treatment, in those receiving the treatment.

Likewise, their mean Lean Body Mass increased by over 10%, while at the same time, there was a 7% decrease in Fat Mass, in the group of adults treated with the Growth Hormone ( GH ). However, none of these measurements changed significantly in the group of patients who were not given the treatment ( the placebo group ).

Furthermore, the base Metabolic Rate, in those given the treatment, had also increased  significantly. At the same time, their fasting plasma Cholesterol levels had decreased. They also had noticeable improvements in both strength and exercise, whereas before this study, these markers had been below normal.

This is their Conclusion

Based on the encouraging positive results of the administration of the plan of treatment using the [ synthetic ] Human Growth Hormone ( HGH ), the researchers then wrote the following in their published report:

"We conclude that Growth Hormone { GH } has a role in the regulation of body composition in adults, probably through its anabolic and lipolytic actions.

https://pubmed.ncbi.nlm.nih.gov/2687691/

https://www.nejm.org/doi/full/10.1056/NEJM198912283212605