Research Studies Involving the Ingredients
- HgH Amino Acids Blend

These Research Studies on the Ingredients
Used in the Formulations of GHR Platinum
Prove that these Anti Aging Products Really Work

- HGH AMINO ACIDS BLEND - 

Dr. LE Dorman, MD - Growth Hormone / Amino Acid Blend
Author of "The Methusaleh Factor"

As we age, our body stops producing an adequate supply of HGH amino acids. Out of the 191 amino acids in the Growth Hormone chain, GHR Platinum replenishes the body with the needed blend of Stacked HgH Amino Acids in the Right Ratio and Molecular Weight that helps stimulate and restore the Release of your body’s own natural Growth Hormone. Many substances stimulate the release of Growth Hormone from the pituitary gland. Amino acids ( from HGH chain ), drugs and exercise are among the provocateurs." ( Page 35 )

- L-ARGININE - 

The amino acid - ARGININE has two main purposes in how it works:

It is a precursor to making other substances in the body. The first is that it works by converting into the compound Nitric Oxide. This substance is involved in various metabolic activities in the body. These include the regulation of the flow of blood, cellular activities of the Mitochondria to create energy, and sending signals of communications between the cells.

One of the ways that Nitric Oxide works, is by dilating and relaxing blood vessels. So it functions as a Vasodilator. This improves the flow and circulation of the blood throughout the entire body, which enables more nutrients and oxygen in the blood to supply the organs, muscles, tissues and cells. This aspect also helps to reduce high blood pressure. As a result of these actions, Arginine helps promote a healthy heart function. Therefore, it can be useful in treating such conditions as hypertension, angina, circulatory system diseases and Erectile Dysfunction ( ED ).

At the same time, Nitric Oxide also aids the body in removing waste products from both the Liver and the muscles. In particular, this includes the metabolic waste substances Lactate and Ammonia. This then helps the muscles, and your entire body, to recover quicker from physical exercise and strenuous workouts.

ARGININE helps the body to create proteins. At the same time, it also helps support a good Immune System. Finally, it is also used in the metabolism of Sugars. So it might help improve Insulin Sensitivity. There are some research studies which indicate that it may thus help people suffering from Type 2 Diabetes.

One of the symptoms of the aging process is that our bodies might not produce enough Arginine. Or our bodies do NOT produce it very well. So, it often is necessary for older people to consume more Arginine by using supplements.

In the last thirty years, there have been lots of research studies, which show that increasing the amount of the amino acids of ARGININE and LYSINE we obtain, will help raise the production and then release of Growth Hormone ( GH ) in the body. Both of these amino acids are included in the GHR Platinum Hgh Boosters. Here are just a few of these studies which conclude that ARGININE is a Growth Hormone Releaser ( GHR ).

Growth Hormone, Arginine and Exercise

Jill A Kanaley - Author ( Department of Exercise Science, Syracuse University, Syracuse, New York )

The researcher made the following conclusion: "Most research studies involving the use of Arginine have demonstrated that this amino acid alone will cause increases in resting levels of Growth Hormone by at least 100%.

Growth Hormone Responses to Varying Doses of Oral Arginine

Scott R Collier; Darren P Casey; Jill A Kanaley

The researchers provided this conclusion from the results of their study: Both 5 grams and 9 grams of the amino acid  Arginine produced a significant result in Growth Hormone.

Increased Human Growth Hormone Following Oral Consumption
of an Amino Acid Supplement: Results of a Randomized,
Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects

Am J Ther - Author of the Manuscript

In this research paper, the researcher also wrote concerning the benefits of certain amino acids to stimulate release of Growth Hormone. The author stated that it is well-established that intravenous ( IV ) application of certain amino acids creates significant boosts in the secretion of  HgH. This mainly involves studies using ARGININE, Lysine and Orthinine, which produce noticeable increases in release of Growth Hormone.

A Study of Growth Hormone Release in Man After Oral Administration of Amino Acids

A Isidori; A Lo Monaco; M Cappa

This research stud involved 15 male subjects. They wanted to investigate various outcomes which certain amino acids caused in stimulating Growth Hormone ( GH ). The results of the tests again demonstrated that the oral administration of a combination of two specific amino acids ( 1,200 mg Lysine plus 1,200 mg ARGININE ) produced a release of Somatotropin { related to GH } in the Pituitary Gland and also Insulin.

Acute Effect of Amino Acid Ingestion and Resistance Exercise
on Plasma Growth Hormone Concentration in Young Men

R R Suminski; R J Robertson; F L Goss; S Arslanian; et al ( Human Performance Laboratory, University of Houston, TX )

In this clinical trial, there were 16 men who participated. They were each given a series of four tests, randomly.

First they ingested a Vitamin C placebo. Then they performed a session of resistance exercise.

Next they were given 1,500 mg L-ARGININE and 1,500 mg L-Lysine and then did another session of resistance exercise.

Thirdly, they were given the amino acids, and then did not do any exercise.

Finally, they were given the placebo, and also did not do any exercise.

Measures were taken at intervals of 30, 60, and 90 minutes during the two sessions of exercise. The levels of Growth Hormone ( GH ) were higher compared to the two tests involving no exercise. They observed no differences in Growth Hormone levels between the exercise trials.

As a result of their data, they concluded that consumption of of 1,500 mg arginine and 1,500 mg Lysine immediately before resistance exercise does not affect Growth Hormone levels that the exercise would normally cause.

However, when the same amino acid combination ( 1,500 mg arginine and 1,500 mg Lysine ) was taken in basal conditions, ( at rest, with no exercise done afterwards ) there was a sharp increase in the secretion ( release ) of Growth Hormone.

- L-LYSINE - 

L-LYSINE is one of the eight ( 8 ) "Essential" amino acids. These are the ones which our bodies can NOT make. So we have to consume them from proteins we eat. Or we have to obtain them from supplements that contain them in readily available forms, that our bodies can then use.

Lysine is one of the critical amino acids which is needed to make the other proteins in the body. It is necessary to create muscle tissues. It is also necessary to produce hormones, enzymes and anti-bodies. It also has an important role in absorbing the mineral calcium, while it helps to reduce the loss of calcium in urine. It also lowers cholesterol levels.

Like the amino acid Glutamine, it also aids in healing and repairing of tissues and cells recovering from wounds. As a Binding Agent, it works in this way to help increase the number of new cells in a wound that is healing. And together with  the amino acid GLYCINE, it is also required to create Collagen, that is used for hair, nails, skin and the various connecting tissues in the body.

It is also a precursor to L-Carnitine, ( a compound found in most cells of the body ), derived from amino acids, that is essential for a proper and healthy functioning of the nervous system. Carnitine carries LONG-CHAIN FATTY ACIDS  across the Mitochondria of the cells and then burns them into working energy. It then eliminates the toxins produced by that metabolic process out of the cells. Lysine is also vital for normal physical growth. Therefore, a lack of the amount of Lysine in the body can lead to various health issues, including slow physical growth, nausea, dizziness and fatigue.

Lysine is also a precursor for L-Carathine which is also necessary for healthy functioning of the nervous system.

There has been much research during the last thirty years, that shows increasing the consumption of the amino acids of Arginine and LYSINE will help increase the production and release of Human Growth Hormone ( HGH ). Both of these amino acids are included in the GHR Platinum Hgh Releasers. These clinical studies and research trials clearly prove that LYSINE is a Growth Hormone Releaser ( GHR ).

Three of the research studies above involving Arginine also include LYSINE, proving that LYSINE is likewise a Releaser of Growth Hormone ( GHR ).

- L-GLUTAMINE - 

GLUTAMINE is a critical amino acid that supports healthy functioning of the brain. It is vital for the synthesis of both RNA and DNA. Growth Hormone ( GH ) promotes a process that is called "NeuroGenesis". This is how new neurons are synthesized in the brain. It also supports the maintenance and functioning of existing brain cells.

In a like manner, Growth Hormone levels also affect the levels of NeuroTransmitters in the brain, which are critical for many activities and functions in the body. Specifically, Glutamine is a powerful amino acid that is also precursor for the making of the NeuroTransmitters GABA and Glutamate. These brain NeuroTransmitters also help to regulate and support various cognitive functions, such as mood, concentration and memory. GABA is also included in the formulation of the GHR Platinum products as one of the HgH Enhancers.

Science researchers know that even small amounts of supplementing with additional Glutamine are able to promote a positive increase in the levels of Growth Hormone in the body. Many research studies have shown that using just 2 mg of this powerful amino acid could temporarily elevate Human Growth Hormone ( HGH ) levels by as much as 78%.

Glutamine is also precursor to making the amino acid Arginine - which is clinically proven to support the increase in production and secretion of Growth Hormone in your pituitary gland. So when you eat more proteins that contain  Glutamine, or you increase your consumption with supplements, you enable your body to elevate the levels of Arginine and the NeuroTransmitters GABA and Glutamate. And there are many research studies which have already shown that both Arginine and Glutamine stimulate the release of Growth Hormone.

So how does Glutamine work to cause a release of your Growth Hormone? The NeuroTranmitter Glutamate has a significant part in stimulating the Somatotrophs in the pituitary gland. These are the particular cells in the pPituitary that actually cause the production and secretion ( release ) of Growth Hormone.

There is also a link between Growth Hormone and Fat Burning in the body. GH stimulates the break-down of body fats, through a process called "Lipolysis". This is how fats and other lipids are broken down and converted to Fatty Acids.  Likewise, there is also a similar connection between Growth Hormone and the metabolism of carbohydrates. This then has a direct impact of blood sugar levels. So Glutamine plays an important role on the Digestive processes and also the subsequent conversion of Starches, Sugars and Fats into energy through healthy metabolism.

Thus this vital amino acid can have a positive affect on levels of body fat, sugar and weight loss. Thus it is important to keep sufficient levels of both Glutamine ( and Arginine ), which stimulate the production and release of your own natural Growth Hormone. This then benefits your overall health and well-being in multiple ways, both physically and mentally.

At the same time, by improving the metabolism of both carbohydrates and fats in the body, you can achieve weight loss or maintain a proper and healthy weight balance. The results will then cause a corresponding increase in the production and release of ( more of ) your own Human Growth Hormone. How does this happen?

Various clinical research studies clearly show and prove that excess BODY FAT, particularly BELLY FAT, will negatively slow down ( or decrease ) both the production and then the release of Growth Hormone. The amount of fat that men and women carry in their bodies, especially in their bellies, adversely impacts the production of Growth Hormone that is made and released from their pituitary glands. So losing weight, especially belly fat, is one of the best things that you can do to boost the secretion of HGH. The GHR Platinum products can help you to do just that.

Glutamine is also the most abundant amino acid found in the blood and in body fluids. There it has several important functions. It is used to create proteins, produce energy, and help with detoxification and removal of waste products, such as Ammonia, from metabolic processes.

Furthermore, this amino acid is needed for proper digestive function ( as explained above ) and good intestinal health. It also supplies energy for white blood cells and for growth and maintenance of certain cells in the intestines. There, this amino acid helps to maintain the barrier which is between the inside of the Intestines and the rest of the body. In this way, it enables you to maintain a healthy gut. This protects against getting what is called a "Leaky Gut". In this way, it works to support a healthy Immune System, which helps to protect you from infection, sickness and disease.

Deficiencies of this amino acid can occur when a person is experiencing a lot of stress, or has an illness or severe injury. In those times, the body actually needs an abundant supply of Glutamine for healing and recovery from wounds. Specifically, the body requires it for repairing damaged tissues and cells.  Consequently, if the body needs more Glutaminethan it can make on its own, it must get it elsewhere. As a result, the body might then break down muscle proteins, in order to release more of this amino acid. This is what happens often times when a person gets sick or injured.

Excess stress causes levels of the hormone Cortisol to rise. This is why it is known as the "Stress Hormone". How does this affect HgH levels in the body? Researchers also know that cortisol can block the production of Growth Hormone. So if you can reduce the amount of stress you have in your body, by maintaining good levels of Glutamine - you also decrease the levels of cortisol that block the production and release of the very Growth Hormone you need and want.

Here is one research study that shows an increase of GLUTAMINE causes an increase in Growth Hormone levels:

Increased Plasma Bicarbonate and Growth Hormone After an Oral Glutamine Load

Welbourne, TC ( Department of Physiology, Louisiana State University College of Medicine, Shreveport, LA )

This clinical test evaluated the effects of Glutamine on circulating Growth Hormone concentrations. Or oral load of this amino acid was given to 9 healthy participants. The findings demonstrated that a surprisingly small amount of this amino acid was capable of boosting alkaline ( bicarbonate ) reserves as well as plasma Growth Hormone.

- L-GLYCINE - 

L-GYCINE is the amino acid used the most in creating Collagen. Collagen is needed for the hair, nails, skin and various connecting tissues throughout the body. This amino acid also helps in making bones, muscle ( and energy in the muscles ) supporting healthy brain functioning, and supports proper and healthy sleep patterns.

Glycine is used to make the TriPeptide Glutathione ( an AntiOxidant found in the cells ). This substance is created from the 3 amino acids: Glutamic Acid, Cysteine, and GLYCINE. But as we get older, the ability of our bodies to make this important AntiOxidant decreases. Thus most likely we need to get more of it by supplements as we age.

The AntiOxidant Glutathione helps to prevent damage and disease to the organs ( especially the Liver ), tissues and cells that Free Radicals can cause. When damaged cells in the Liver form Fibrous Tissues, they can turn into scars. Or the Liver can become diseased through accumulation of excessive fat ( "Fatty Liver" ), alcohol consumption and immune attacks.

Glycine also works as a NeuroTransmitter. In this capacity, it works in the processing of motor and sensory information, which enables vision, hearing and movement. It also works by helping to calm the central nervous system. And similar to the amino acid Glutamine, the ability of our bodies to make it, can become negatively impacted during times of stress, sickness or injury. Therefore, it is necessary to help repair tissues and cells and for healing of wounds.

Finally, this amino acid is involved in the digestive process. It helps to digest fats by managing the release of bile acids from the gall-bladder into the small intestine. Meanwhile, it works as a "Glucogenic Amino Acid", which means that the Liver can convert this amino acid into glucose ( sugar ).

GLYCINE is the second most common amino acid contained in the various proteins of the body. There have been many clinical research studies showing the link between increasing the amount of Glycine and a corresponding boost in the levels of Human Growth Hormone in the body. Here are just some of them:

The Effect of Glycine Administration on the Characteristics
of Physiological Systems in Human Adults: A Systematic Review

Janjira Soh; Shivaanishaa Raventhiran; Jasinda H Lee; Zi Xiang Lim; Jorming Goh; Brian K Kennedy; Andrea B Maier

There is a degradation of our physical bodies and systems as we grow older. It leads to age-related diseases. However, the amino acid Glycine can increase the lifespan in healthy individuals. Additionally it could reduce inflammation, which is associated with various diseases and health conditions. This review summarized the evidence gathered from various studies involving  the use of Glycine on the characteristics of eleven physiological systems in adults.

The researchers concluded that the nervous system showed the most positive improvements from supplementation with Glycine. This also included improved mental functioning from long-term use of Glycine application. Moreover, this specific amino acid helped enhance the quality of sleep in healthy individuals.

Stimulatory Effect of Glycine on Human Growth Hormone Secretion

K Kasai; M Kobayashi; S I Shimoda

In this clinical study, the amino acid "Glycine was given to 31 participants. Of these, 19 were normal adults who were not obese. The remaining 12 were patients having partial gastrectomy. In the first group of health individuals, they observed a clear and noticeable increase of serum Human Growth Hormone levels. The results of the tests showed that Glycine is capable of stimulating the pituitary gland to secrete HgH.

Glycine Stimulated Growth Hormone Release in Man

K Kasai; H Suzuki; T Nakamura; H Shiina; S I Shimoda

Here the researchers gave different dosage amounts of Glycine, in quantities of 4, 8 and 12 grams, to normal subjects, over a time period of 15 or 30 minutes. They then studied the effects of the administration that the amino acid had on functioning of the Pituitary Gland.

The dosage of 4 and 8 grams of Glycine caused a significant increase in serum GH levels. However, there was a far greater observable increase in serum Growth Hormone levels after the infusion of 12 grams.

The results of the findings suggests that Glycine could have a significant part in the activities of both the Hypothalamus and the Pituitary Glands. These are the two glands involved in the making and release of Human Growth Hormone.

Reduced Plasma Glycine Concentration in Healthy and Chronically Diseased
Older Adults: a Marker of Visceral Adiposity?

Lars Nj Deutz; Raven A Wierzchowska-McNew; Nicolaas Ep Deutz; Mariëlle Pkj Engelen
( Center for Translational Research in Aging and Longevity, Department of Kinesiology and Sport Management,
Texas A&M University, College Station, TX )

Here the researchers noted that previous clinical studies have demonstrated that a reduced plasma concentration of the amino acid Glycine is connected to abdominal obesity ( belly fat ). However, the reason for this is not yet known.

Thus, this particular study investigated whether lower plasma concentrations of Glycine in older men and women were independently associated with ( visceral ) adiposity { condition of being fat }, age, sex, presence of chronic disease and glucose intolerance. Certain other factors were also evaluated to find a possible cause of this condition.

They gathered 102 older adults, consisting of 47 males and 55 females. They evaluated their body composition and Visceral Adipose Tissue ( VAT ). The strong association between lower plasma Glycine and increased fat mass in these older people turned out to exist regardless of their age, gender, body weight, lean mass or body mass index ( BMI ), and the presence of COPD.

They concluded that lower levels of plasma Glycine in older populations can be considered an indication of visceral body fat, independent of the above factors, including also whether or not they had any chronic disease.

- L-TYROSINE - 

The amino acid - TYROSINE is made from Phenylalanine, one of the 8 "Essential" amino acids. Therefore, we must eat enough of Phenylalanine in our consumption of proteins, or else obtain it from taking supplements. Consequently, if we do not have enough of Phenylalanine, we will also be lacking in Tyrosine as well.

Tyrosine plays a role in the building of proteins. In this way, it is involved in the production of the various Thyroid Hormones ( Thyroxin ), which helps regulate metabolism, adreno-cortical hormones, Melanin ( a pigment that is found in the hair, skin and iris of the eyes ), Enzymes, and various NeuroTransmitters.

The NeuroTransmitters in our brains relate to our various cognitive abilities, such as mood, focus, concentration, memory, working memory, cognitive flexibility ( ability to switch tasks or change thoughts ) and following instructions.

Thus this amino acid is a precursor for the NeuroTransmitters / Hormones - Dopamine, Epinephrine, Norepinephrine,  Adrenaline and Noradrenaline. And these substances can affect the secretion of HgH in the pituitary gland.

Dopamine is critical for our mental functioning and mood. It regulates the reward and pleasure centers. This important
brain substance is also vital for memory and motor skills.

Adrenaline and Noradrenalin are hormones that are responsible for what is called the "Fight-or-Flight Response" in stressful situations. They enable our bodies to stand and fight, or flee and run - from a perceived or actual attack or harm.

In these ways, this particular amino acid helps to balance the affects of excessive physical and mental stress. When we are under a high level of stress, we often have difficulty thinking clearly and remembering things. Research studies have shown that supplementation with Tyrosine helped to improve such cognitive ability. Numerous other studies which have been conducted, proved that Tyrosine reduces anxiety and stress, and assists people to be more mentally alert.

Likewise, Tyrosine has a part in the making of "Enkephalins". These are special substances in the brain which provide pain-relieving effects to the body. They are critical to the healthy functioning of our brains, because they are responsible for transmitting nerve impulses and signals, and prevent conditions such as depression.

Additionally, this amino acid also plays a role in the regulation of Blood Pressure, and also helping to reduce BODY FAT. Finally, it is also an AntiOxidant, helping to protect the body from damage caused by Free Radicals to organs, tissues, muscles and cells.

There has been much research to discover how TYROSINE stimulates the pituitary gland to cause it to secrete ( more ) Growth Hormone. This increased release of our GH, through the work of Tyrosine, may occur at particular times, especially when under stress.

One particular study found that it has a significant part in supporting increased levels of both HGH and IGF-1, especially under conditions of stress or during high-intensity workouts. Scientists believe that it works by activating the enzyme, called Tyrosine Kinase, which then acts like a messenger, which signals the body to begin various metabolic processes related to the production and release of Growth Hormone.

Moreover, according to various scientific studies, the ability of Tyrosine to elevate the release of our Human Growth Hormone, is increased - when it is combined with certain other amino acids. Thus research studies have already shown that combining TYROSINE with the amino acids ARGININE and LYSINE can cause a more significant boost in levels of HGH, when compared to taking it alone.

There is already plenty of research which concludes that elevating the intake of both ARGININE and LYSINE, especially when these two combined together, leads to an increased production and release of Growth Hormone.

Effect of Tyrosine Supplementation on Clinical and Healthy Populations
Under Stress or Cognitive Demands - A Review

Bryant J Jongkees; Bernhard Hommel; Simone Kühn; Lorenza S Colzato

( Institute for Psychological Research & Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands
& Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany )

Tyrosine is the precursor of Dopamine ( DA ) and Norepinephrine ( NE ). Supplementation with this amino acid might counteract the effects of declines in performance in cognitive functioning caused by decreases of these neurotransmitters.

In this review, they evaluated the available studies involving Tyrosine and cognition and behavior. They wanted to find out if and when administration of Glycine can be beneficial for cognitive activities.

The results of their review suggested the following. Tyrosine does appear to effectively enhance performance in cognitive activities. This is true particularly in short-term stressful situations and / or such situations that require great cognitive functioning. The researchers concluded that Tyrosine can improve cognitive activities.

Behavioral and Cognitive Effects of Tyrosine Intake in Healthy Human Adults

Adrian Hase; Sophie E Jung; Marije aan het Rot
( Department of Psychology, University of Groningen, Netherlands )

The amino acid Tyrosine is the precursor to the catecholamine brain NeuroTransmitters Dopamine and Norepinephrine. Thus, increasing the intake of this amino acid could subsequently cause an increase in mental / cognitive functioning.

The researchers performed a systematic review to study the effects of administering Tyrosine on cognition and behavior. They examined fifteen research studies. All of these studies, except for one of them, involved using a Tyrosine load during a single test session. In most behavioral studies, they noted that there were no significant effects that Tyrosine had on exercise performance.

However, the research studies applying neuro-psychological measures found the following. The amino acid Tyrosine could sharply counteract degradations in the cognitive functions of working memory and information processing, which are induced by demanding cognitive situations. They concluded that the increase of Tyrosine on cognition abilities could be explained by its ability to neutralize depleted levels of brain catecholamines. Thus, the evidence suggests that Tyrosine could help healthy individuals who experience demanding cognitive situations or conditions.

Tyrosine Promotes Cognitive Flexibility:
Evidence From Proactive vs. Reactive Control During Task Switching Performance

Laura Steenbergen; Roberta Sellaro; Bernhard Hommel; Lorenza S Colzato
( Institute for Psychological Research, Leiden University, Leiden - Netherlands )

The amino acid Tyrosine has been shown to increase levels of the NeuroTransmitter Dopamine ( DA ) in the brain. Various research studies have provided evidence that supplementation with Tyrosine can enhance various aspects of cognitive control in situations with high cognitive demands.

This was a Double-Blind, Placebo-Controlled, Randomized Study. It involved 22 healthy adults who performed in a task-switching activity. In this study, the researchers investigated whether Tyrosine promotes cognitive flexibility, a particular cognitive-control activity that is believed to regulated by Dopamine. They examined the effects of Tyrosine on proactive versus reactive control during what is called Task Switching Performance. This is a function that provides a relatively well-established marker of cognitive flexibility.

Here is the outcome of their study. Tyrosine encouraged cognitive flexibility compared to the placebo. This finding supports the belief that Tyrosine can improve cognitive flexibility by supplying cognitive resources.

Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task

Lorenza S Colzato; Bryant J Jongkees; Roberta Sellaro; Bernhard Hommel
( Institute for Psychological Research, Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands )

This study focused on the effects of supplementation with Tyrosine on the updating ( and monitoring ) of Working Memory which is a key cognitive-control function. The researchers tested the idea that Tyrosine provides resources needed for cognitive-control operations.

This study was the first to demonstrate that Tyrosine supplementation supports improved Working Memory updating. As they expected, in more difficult cognitive conditions, the more sensitive was the effects of the dosage of Tyrosine. This supported their hypothesis that only tasks with challenging cognitive demands benefit from Tyrosine increase. This may be as a result of the following. More demanding cognitive functions are smore likely to consume the available cognitive resources, which can then be re-supplied through more Tyrosine.

Increased Human Growth Hormone Following Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects

Charmaine S Tam; William D Johnson; Jennifer Rood; Amy L Heaton; Frank L Greenway

This was a Randomized, Placebo-Controlled, Double-Blind, Crossover Study. It involved 16 healthy adults, consisting of 12 men and 4 women. They were about 32 years old, ±14 years. The researchers wanted to investigate if the amino acid  Tyrosine could affect the release of HgH.

Each of the participants received both the amino acid supplement and a placebo, after an overnight fast. Each of them then completed all study visits. The order of treatment was randomized. Each treatment was separated by a one-week washout period.

Here are the results of the trial. The primary outcome was the percentage change in Growth Hormone from baseline to 120 minutes and the area under the curve of HgH over baseline. At 120 minutes, levels were increased by 682% ( 8 times ) compared to baseline. Moreover, a significantly higher mean area under the curve was seen for when the amino acid dose was given compared to taking the placebo.

These results demonstrated that a single dose of the oral amino acid Tyrosine was more than enough to produce a significant increase in levels of Growth Hormone in healthy adult males and females.